Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
نویسندگان
چکیده
منابع مشابه
Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism.
The past 50 years have witnessed a monumental advance in our understanding of pharmacodynamics (what drugs do to the body) and pharmacokinetics (what the body does to drugs). In the realm of pharmacokinetics, dozens of enzymes responsible for drug biotransformation and transporters responsible for the absorption, distribution and excretion of drugs have been identified. Drug biotransformation (...
متن کاملNuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.
Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase III). Genes involved in drug metabolism and disposition are induced by xenobiotic-activated nuclear receptors (NRs), i.e. PXR (pregnane X receptor) and CAR ...
متن کاملSXR, a novel steroid and xenobiotic-sensing nuclear receptor.
An important requirement for physiologic homeostasis is the detoxification and removal of endogenous hormones and xenobiotic compounds with biological activity. Much of the detoxification is performed by cytochrome P-450 enzymes, many of which have broad substrate specificity and are inducible by hundreds of different compounds, including steroids. The ingestion of dietary steroids and lipids i...
متن کاملInduction of drug metabolism: the role of nuclear receptors.
Induction of drug metabolism was described more than 40 years ago. Progress in understanding the molecular mechanism of induction of drug-metabolizing enzymes was made recently when the important roles of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), two members of the nuclear receptor superfamily of transcription factors, were discovered to act as sensors for li...
متن کاملThe tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.
The expression of many genes involved in xenobiotic/drug metabolism and transport is regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and pregnane X receptor (PXR). These receptors establish crosstalk with other nuclear receptors or transcription factors controlling signaling pathways that regulate the homeost...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Metabolism Reviews
سال: 2012
ISSN: 0360-2532,1097-9883
DOI: 10.3109/03602532.2012.740049